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Pioglitazone hydrochloride monotherapy - the chief changes Averc jaiuidice; fatty degeneration of liver Avith indistinctness of lobules, and small cell infiltration of connective tissue; fatty degeneration and cloudy swelling of epithelium of kidney and acute parenchymatous nephritis; minute haemorrhages in diH'erent organs; sAvelling of spleen; intestinal changes, observed in one case only but in this one very fu)tal)le, namely, marked vascularity, numerous htemorrhages, and superficial erosions of mucous membrane throughout Avhole intestinal tract:

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